Protective Effect of Aframomum meleguetaphenolics
Against CCl4-Induced Rat Hepatocytes Damage; Role
of Apoptosis and Pro-inflammatory Cytokines inhibition
Abstract
Aframomum melegueta is a commonly used African spice. Through a
hepatoprotective bioassay-guided isolation, the chloroform fraction ofA.melegueta seeds yielded one new diarylheptanoid
named 3-(S)-acetyl-1-(4′-hydroxy-3′, 5′-di methoxyphenyl)-7-(3″,4″,
5″-trihydroxyphenyl)heptane (1), and two new hydroxyphenylalkanones,
[8]-dehydrogingerdione (2) and [6]-dehydroparadol (3), in addition to six known
compounds (4–9). The hepatoprotective effect of A. meleguetamethanol extract,
sub-fractions and isolated compounds was investigated using carbon
tetrachloride (CCl4)-induced liver injury in a rat hepatocytes model. The methanol,
chloroform extracts and compounds 1, 5, 8 and 9 of A. melegueta significantly inhibited the elevated
serum alanine aminotransferase (ALT), thiobarbituric acid reactive substances
(TBARS), tumor necrosis factor (TNFα), interleukin-1beta (Il-1β), caspase3 and
9 and enhanced the reduced liver glutathione (GSH) level caused by CCl4 intoxication.
These results indicate thatA.melegueta extracts,
and isolated compounds play a protective role in CCl4 induced
acute liver injury which might be due to elevated antioxidative defense
potentials, suppressed inflammatory responses and apoptosis of liver tissue.
Chemical Composition and Antioxidant Activities
of Aframomum
sceptrum
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